Endocrine Abstracts

Myostatin (MSTN) is a negative regulator of skeletal muscle growth, while androgens are strong positive regulators of muscle growth and strength. Follistatin (FS) is a binding protein which inhibits MSTN action. Evidences suggest that MSTN and testosterone actions in muscle may be associated. However, the mechanisms of androgens actions are not fully elucidated. The objective of this study was to evaluate the influence of exercise training in the expression of MSTN and FS in o...

Introduction: PATRO adults is an ongoing, international, open, longitudinal, non-interventional study of the long-term safety and efficacy of recombinant human GH (rhGH; Omnitrope, Sandoz). The study will provide further data on the long-term safety of rhGH in adult patients with severe GH deficiency (GHD). Here, we present safety data from an interim analysis.Methods: Adults who are receiving treatment with Omnitrope and who have provided informed conse...

Introduction: PATRO adults is an ongoing, international, open, longitudinal, non-interventional study of the long-term safety and efficacy of Omnitrope (Sandoz), a recombinant human GH (rhGH). This study will provide additional data on the long-term safety of rhGH in adult patients with severe GH deficiency (GHD). Here, we present safety data from an interim analysis.Methods: Eligible patients are male or female adults who are receiving treatment with Om...

Cushing’s disease is a debilitating endocrinopathy characterized by excessive cortisol levels in the blood which may be produced from tumours of the pituitary gland. The only way to achieve long term cure of Cushing’s disease is by Transphenoidal removal of the adenoma. ketoconazole, inhibit steroid (cortisol) production in the adrenal glands.The use of glucocorticids treatment before and after hypophisectomy is a classic management in the peri...

Introduction: Patients with severe cerebral Trauma are a risk population for developing hipopituytarism. Diagnosis of GHD need to study pituitary gland reserve with a stimulation test. Insulin Tolerance test (ITT) is the best standard test, although has important contraindication in these patients and its realization is not always a possible. We evaluate the diagnostic capacity of two alternative test (Glucagon Test an GHRH-GHRP6 test) and compared them with ITT.<p class="...

Sex hormone-binding globulin levels are low in adult subjects with obesity when compared to normal-weight individuals. Obesity is associated with higher tumor necrosis factor alpha (TNFα) plasma levels and lower adiponectin levels. Moreover, we have recently elucidated the molecular mechanisms by which TNFα and adiponectin regulate hepatic SHBG production. The main objective of this study was to assess if the adult associations between TNFα, Adiponectin and SHBG...

Background: Acromegaly is a rare disorder associated with excessive levels of growth hormone(GH) and insulin-like growth factor-1(IGF-1). GH/IGF-1 excess leads to morphologic craniofacial and acral changes as well as cardiometabolic complications, but the phenotypic changes and presentation differ across species.Aim: To present the resemblances and distinctive features of acromegaly in humans, cats and dogs.Methods: A literature re...

Background: Germ cell tumors (germinoma, teratoma, embryonal carcinoma, yolk sac tumor and choriocarcinoma) constitute 0.3–3.4% of all primary intracraneal tumors. Germinoma is the most common and of better prognosis.Aim: Describing the behaviour of germ cell tumors of the pituitary–hypothalamic region: location, clinical characteristics, diagnosis and follow-up.Material and methods: Review of medical records of patients ...

Ghrelin was isolated from stomach by its ability to stimulate growth hormone (GH) release through the GH-secretagogue receptor (GHS-R1a). However, ghrelin/GHS-R expression in multiple tissues and tumor types suggested additional roles for this tandem. Ghrelin, a 28-aminoacid peptide, requires a unique O-acylation at its Ser-3 residue to bind GHS-R1a and release GH. Conversely, unacylated ghrelin (UAG), initially considered inactive, seems to play distinct metabolic role...

Background: From 2018 to 2020, the Birmingham Children’s Hospital (BCH) Diabetes Team was a negative regional outlier for the National Paediatric Diabetes Audit (NPDA) seven key care processes. In 2021, the BCH team embarked on a Quality Improvement (QI) journey using Plan-Do-Study-Act (PDSA) cycles to improve care.Objective: Review PDSA cycles of improvements from 2021 to 2023.Methods...